The Panthers travel to San Francisco in search of their fourth consecutive road victory. The franchise has not won four straight road games within a season since winning their first seven road games of 2015.
Carolina is 13-9 in 22 all-time regular-season meetings vs. the 49ers, including a 7-4 record in San Francisco. The Panthers’ .636 road winning percentage against the team is the fifth-best among all opponents, while their seven road victories are the most among non-NFC South opponents.
Former NFC West Division rivals (1995-2001), the Panthers won the first six games in the series before moving to the NFC South in 2002. Their 6-2 (.750) record vs. San Francisco since then is tied for the best winning percentage vs. a non division opponent in franchise history.
The 49ers have won the past two meetings in the series, including a 37-15 victory in Charlotte (10/09/22) in their last matchup.
The first Monday Night Football game in franchise history was against San Francisco, a 34-21 loss in Carolina (09/29/97).
The Panthers are 10-8 all-time on Monday Night Football, including a 3-3 record on the road. Their .556 winning percentage is the 10th best among all teams in games played on Monday.
This is RB Christian McCaffrey’s first game against the Panthers since being traded to the 49ers in the middle of the 2022 season. McCaffrey ranks fifth in Panthers history in scrimmage yards (7,272) and tied for fifth in touchdowns (50).
About Carolina
- The Panthers have posted a 9-4 record (.692) in one-score games, the third-best winning percentage in the league since 2024. Since becoming the Panthers head coach, Canales has gone 4-1 in five overtime games, tied with Atlanta (1-4) for the most overtime games played since 2024.
- On the 46 opposing possessions that began after a Panthers kickoff this season, the defense has allowed 1.57 points per drive, the fifth-lowest average in the league and just a 15.2% touchdown allowed percentage, the third lowest.
- Since entering the league (2023), QB Bryce Young has led 10 game-winning drives in the fourth quarter/overtime in his career, including four this season. His 10-career game-winning drives are tied for the third most by a player before turning 25 since 2000, and tied for the most among all quarterbacks since 2023.
- On the season, RB Rico Dowdle ranks fourth in the league with 833 yards rushing, including 750 yards since Week 5 (107.14 per game). Among players with at least 100 carries this season, Dowdle’s 5.0 yards per carry ranks seventh in the league, while his 17 explosive runs (12+ yards) are tied for fourth in the league. In total, Dowdle has produced 1,030 scrimmage yards, eighth best, including 927 (132.4 per game) over the last six weeks
- Tetairoa McMillan leads all rookies in receptions (54) and receiving yards (748), and is tied for second in receiving touchdownsn(four). Through 11 games, he already ranks in the top five in receptionsn(4th), receiving yards (4th), and receiving touchdowns (t-5th) among rookies in Panthers history.
- This season, DT Derrick Brown has 33 tackles, 3.0 sacks, and five passes defensed when lined up as a interior defensive lineman this season, one of only two players to do so. Over the last five seasons (since 2021), 12 players (14 occurrences) have registered at least 30 tackles, 3.0 sacks, and five passes defensed as an interior defensive lineman.
About San Francisco
- The 49ers offense has scored 26 points in their 2-minute offense this season (drives beginning at 2 minutes left in half or less), the 3rd-most in the NFL (Dal. – 33; Den. – 27).
- Since 2023, the 49ers defense has held opposing receivers to an average of 9.9 yds. per recept., which is the lowest opponent yds. per recept. in the NFL during that span.
- In 2025, Purdy has completed 67 of his 99 passing atts. (67.7%) for 786 yds. and 7 TDs with a passer rating of 98.3 to go along with 8 rushes for 23 yds. (2.9 avg.).
- A five-time AP All-Pro (First-Team – 2019 & 2023; Second-Team – 2018, 2022 & 2024) and Pro Bowl selection (2019-20 & 2022-24), TE George Kittle ranks 2nd in the NFL in rec. yds. (7,631) among all active TEs since entering the NFL in 2017. Kittle owns the top 3 and 5 of the top 7 performances for most rec. yds. in a game by a TE in franchise history.
- Since entering the league in 2017, McCaffrey has registered 66 games with 100-or-more yds. from scrimmage which is the most among active NFL RBs. In 2025, McCaffrey has registered 193 rushes for 707 yards (3.7 avg.) and 6 TDs to go along with 74 recepts. for 732 yds. (9.9 avg.) and 5 TDs.
Panthers vs 49ers
How to Watch
Kickoff: 8:15 p.m. ET ESPN: Play-by-Play: Joe Buck; Analyst: Troy Aikman; Sideline: Laura Rutledge & Lisa Salters
Radio: WRFX 99.7FM in Charlotte market –Play-by-Play: Anish Shroff; Analysts: Luke Kuechly & Jake Delhomme; Sideline: Kristen Balboni
Per Release
